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Scientific Session I: Tumor

Monday, April 30 | 2:00 pm - 5:30 pm

Moderator(s): Randy Lynn Jensen, MD, PhD, FAANS; Pamela Stuart Jones, MD, MPH

2:00 pm - 2:04 pm

Introduction of the Ronald L. Bittner Lecture

Steven N. Kalkanis, MD, FAANS

2:05 pm - 2:39 pm

Ronald L. Bittner Lecture: Historical and Future Perspectives in Brain Tumor Therapy - Through the Surgeon’s and Patient’s Eyes

Mark L. Rosenblum, MD, FAANS(L)

Mark L. Rosenblum, MD, FAANS(L), is currently chairman emeritus of the department of neurosurgery in the Henry Ford Health System (HFHS). He has received many awards for his research and clinical work, including the first Charles B. Wilson Award from the AANS and CNS for life-long contributions to neuro-oncology. He has published seven books, 240 articles and chapters, trained 63 neurosurgeons and raised $45 million in philanthropy for neuroscience.

Dr. Rosenblum has served on several hospital and industry boards. He is presently the chief medical advisor for a healthcare process improvement company, is a consultant for Navigant and is an adjunct professor in the department of health management and policy in the School of Public Health at the University of Michigan. He has particular interest in the value of integrated specialty care, including the development of centers and institutes, and developing innovative delivery processes “through the eyes of the patient.”

2:40 pm - 2:49 pm

504. Five-aminolevulinic acid (5ALA) for fluorescence-guided surgery of high-grade gliomas (HGG): U.S. experience interim analysis.

Isabelle M. Germano, MD, FAANS

2:50 pm - 2:59 pm

505. Systemic and Local Immunosuppression In Patients With High-Grade Meningiomas

Derek Li

Young Neurosurgeons Medical Student Abstract Award

3:00 pm - 3:09 pm

506. Genotype Based Local Targeted Therapy for Glioma

Ganesh Mani Shankar, MD

Mahaley Clinical Research Award

3:10 pm - 3:19 pm

507. Analysis of Mutational Processes in 23 Adult Hemispheric Diffuse Gliomas Identifies DNA-Damage Repair Deficiency as a Major Contributor to Gliomagenesis.

Koray Ozduman, MD (Turkey)

Brainlab Neurosurgery Award

3:20 pm - 3:29 pm

508. Convolutional Neural Networks Provide Rapid Intraoperative Diagnosis Of Neurosurgical Specimens Imaged With Stimulated Raman Histology

Todd Hollon, MD

Ronald L. Bittner Award on Brain Tumor Research

3:30 pm - 4:00 pm

Beverage Break in the AANS Exhibit Hall and Learning Center

4:01 pm - 4:10 pm

509. Whole Exome and Targeted Sequencing of Adult Infiltrating Astrocytomas: Experience at a Single Institution.

Rohan Ramakrishna, MD, FAANS

Preuss Research Award

4:11 pm - 4:20 pm

510. The Risk of Malignancy after Stereotactic Radiosurgery

Douglas S. Kondziolka, MD, FAANS

AANS/CNS Joint Section on Tumors Neuro-Oncology Trainee Award - Amparo Myrelle Wolf, MD, PhD

4:21 pm - 4:30 pm

511. CRISPR Improved: Inducible CRISPR-Interference Achieves Specific and Reversible PIKE-A Silencing in Glioblastoma

Arman Jahangiri

4:31 pm - 4:40 pm

512. RNA Deconvolution Reveals Distinctive Immunogenetic Landscapes in Nf2 and non-Nf2 Meningiomas

Jacky Yeung, MD

4:41 pm - 4:50 pm

513. Glioma Stem Cells Driven by Distinct BMI-1 and EZH2 Transcriptional Pathways Targeted Separately or Synergistically

Andrew E. Sloan, MD, FAANS

4:51 pm - 5:00 pm

514. Multi-agent vs. Single-agent Intraventricular Chemotherapy for Patients with Neoplastic Meningitis (NM): Changing the Reputation of a Fearsome Disease

Samer Zammar, MD

5:01 pm - 5:10 pm

515. Integrative Analysis Implicates MYC and MAX in Functional Pituitary Adenomas

Douglass Warren Tucker

5:11 pm - 5:20 pm

Whole-Sellar Stereotactic Radiosurgery for Cushing’s Disease: Results from a Multicenter, International Cohort Study

Matthew Shepard, MD