Patient Information

Treatment Options for Cerebral Aneurysms

April, 2003

Updated August, 2009

By Deepa Soni, MD (updated by Jeffrey E. Thomas, MD, FACS)

What is an aneurysm?

A cerebral or intracranial aneurysm is a dilation of an artery in the brain that results from a weakening of the inner muscular layer (the intima) of a blood vessel wall. The vessel develops a "blister-like" dilation that can become thin and rupture without warning. The resultant bleeding into the space around the brain is called a subarachnoid hemorrhage (SAH). This kind of hemorrhage can lead to a stroke, coma, and/or death.

The exact mechanisms by which cerebral aneurysms develop, grow, and rupture are unknown. However, a number of factors are believed to contribute to the formation of cerebral aneurysms. These include: 1) hypertension (high blood pressure); 2) cigarette smoking; 3) congenital (genetic) predisposition; 4) injury or trauma to blood vessels; 5) complication from some types of blood infections.

Types of Aneurysms:
An unruptured aneurysm is one whose sac has not previously leaked. An aneurysm ruptures when a hole develops in the sac of the aneurysm. The hole can be small, in which case only a small amount of blood leaks, or large, leading to a major hemorrhage. Every year approximately 30,000 patients in the United States suffer from a ruptured cerebral aneurysm, and up to 6 percent of the population may have an unruptured cerebral aneurysm. The management of both ruptured and unruptured cerebral aneurysms poses a significant challenge for patients and their treating physicians.

Treatment Options:
Today there are three treatment options for people with the diagnosis of cerebral aneurysm: 1) medical (non-surgical) therapy; 2) surgical therapy or clipping; and 3) endovascular therapy or coiling.

Medical Therapy:
Medical therapy is usually only an option for the treatment of unruptured intracranial aneurysms. Strategies include smoking cessation and blood pressure control. These are the only factors that have been shown to have a significant effect on aneurysm formation, growth, and/or rupture. You and your doctor can work together to design an individualized smoking cessation program that is both practical and feasible for your lifestyle. In addition, if you suffer from high blood pressure, your doctor may choose to start you on an antihypertensive (blood pressure lowering) medication and/or diet and exercise program. Finally, periodic radiographic imaging (either MRA, CT Scan or conventional angiography) may be recommended at intervals to monitor the size and/or growth of the aneurysm. Because the mechanisms of aneurysm rupture are incompletely understood, and because even aneurysms of very small size may rupture, the role of serial imaging for cerebral aneurysm is undefined.

Surgical Clipping:
In 1855, Victor Horsley, MD, was the first to surgically treat a brain aneurysm. In 1937, Walter Dandy, MD, introduced the method of "clipping" an aneurysm when he applied a V-shaped, silver clip to the neck of an internal carotid artery aneurysm. Since that time, aneurysm clips have evolved into hundreds of varieties, shapes, and sizes. The mechanical sophistication of available clips, along with the advent of the operating microscope in the 1960s have made surgical clipping the gold standard in the treatment of both ruptured and unruptured cerebral aneurysms. In spite of these advances, surgical clipping remains an invasive and technically challenging procedure.

How is an aneurysm surgically clipped?
An aneurysm is clipped through a craniotomy, which is a surgical procedure in which the brain and the blood vessels are accessed through an opening in the skull. After the aneurysm is identified, it is carefully dissected (separated) from the surrounding brain tissue. A small metal clip (usually made from titanium) is then applied to the neck (base) of the aneurysm. Aneurysm clips come in all different shapes and sizes, and the choice of a particular clip is based on the size and location of an aneurysm. The clip has a spring mechanism which allows the two "jaws" of the clip to close around either side of the aneurysm, thus occluding (separating) the aneurysm from the parent (origin) blood vessel. In the ideal clipping, normal blood vessel anatomy is physically restored by excluding the aneurysm sac from the cerebral circulation.

Endovascular Coiling:
Endovascular techniques for treating aneurysms date back to the 1970s with the introduction of proximal balloon occlusion by Fjodor A. Serbinenko, MD, a Russian neurosurgeon. During the 1980s, endovascular treatment of aneurysms with balloon angioplasty was associated with high procedural rate of rupture and complications. Guido Guglielmi, MD, an American-based neuroradiologist, invented the platinum detachable microcoil, which was used to treat the first human being in 1991. The development of Guglielmi detachable coils (GDCs) and their FDA approval in 1995, revolutionized endovascular treatment of cerebral aneurysms.

The common goal of both surgical clipping and endovascular coiling is to eliminate blood flow into the aneurysm. Efficacy (long-term success or effectiveness of the treatment) is measured by evidence of aneurysm obliteration (failure to be demonstrated by conventional or noninvasive angiography), without evidence of recanalization (any blood flow into the aneurysm) or recurrence (reappearance).

How is an aneurysm endovascularly coiled?
Guglielmi detachable coils, known as GDCs, are soft wire spirals originally made out of platinum. These coils are deployed (released) into an aneurysm via a microcatheter that is inserted through the femoral artery of the leg and carefully advanced into the brain. The microcatheter is selectively advance into the aneurysm itself, and the microcoils are released in a sequential manner. Once the coils are released into the aneurysm, the blood flow pattern within the aneurysm is altered, and the slow or sluggish remaining blood flow leads to a thrombosis (clot) of the aneurysm. A thrombosed aneurysm resists the entry of liquid blood, providing a seal in a manner similar to a clip.

Endovascular coiling is an attractive option for treating aneurysms because it does not require opening of the skull, and is generally accomplished in a shorter timeframe, which lessens the anesthesia given. Nevertheless, important differences remain between clipping and coiling, including the nature of the seal created. Because coiling does not physically reapproximate the inner blood vessel lining (endothelium), recanalization may occur through the eventual compaction of the coils into the aneurysm by the bloodstream.

The long-term durability of coiling is still unknown and not all aneurysms are suitable for coiling. As experience with coiling grows, the indications and pitfalls continue to be refined. Endovascular and coil technology continue to improve: endovascular adjuncts, such as intracranial stents, are now available to assist in coiling procedures; the original platinum microcoil has been refined with ever-improving features such as biological coating and microengineering for efficiency in deployment.

Who performs the procedure?
Surgical clipping of a cerebral aneurysm is always performed by a neurosurgeon, often one with expertise in cerebrovascular disease. Most cerebrovascular neurosurgeons have had 5-7 years of general neurosurgery training and an additional 1-2 years of specialized cerebrovascular training.

Endovascular coiling is done either by a neurosurgeon or by an interventional neuroradiologist. An interventional radiologist has undergone extensive training (3-5 years) in both radiology and interventional (invasive) procedures involving the brain and spinal cord. All neurosurgeons that perform endovascular coiling have undergone additional training in endovascular techniques in addition to full neurosurgery training (5-7 years of residency).

Safety and Common Complications.
Although the frequencies of certain complications vary according to the intervention, both clipping and coiling share the same complications. Rupture of the aneurysm is one of the most serious complications seen in either procedure. Exact frequencies of ruptures are not well documented, but reported rupture rates range from 2 percent to 3 percent for both coiling and clipping. Rupture can cause massive intracerebral hemorrhage (hemorrhagic stroke, or bleeding into the brain) and subsequent coma or death. Although rupture can have catastrophic consequences during either procedure, surgery probably provides a better opportunity to control hemorrhage because of direct access to the ruptured aneurysm and the supplying vessels.

Ischemic stroke (stroke secondary to decreased blood oxygen) is another serious complication frequently encountered in both clipping and coiling. The pattern and distribution of strokes varies according to the aneurysm location and procedure type.

The actual length of the procedure, the associated risks, the projected recovery time, and the expected prognosis (outcome) depend on both the location of the aneurysm, the presence and severity of hemorrhage, and the patient's underlying medical condition. Therefore, each individual case should be discussed with the treating neurosurgeon/physician.

Review of Current Literature
Comparing the safety, effectiveness, and long-term outcome of endovascular coiling to surgical clipping of cerebral aneurysms is a major research initiative in neurosurgery. A randomized, controlled trial (what is a randomized control trial?) is needed to compare the safety and long-term outcome of surgical clipping to endovascular coiling for the treatment of cerebral aneurysms.

Results from the International Subarachnoid Aneurysm Trial (ISAT), a randomized control trial which compared surgical clipping to endovascular coiling in the treatment of ruptured aneurysms, were published in the Lancet in 2002. The results indicated that endovascular coiling is slightly less risky (6.9 percent) than surgical clipping. These results are informative, but they must be interpreted with caution (AANS/CNS position statement) because this study was the first of its kind, and the follow-up period for the patients was short (one year). The durability or long-term permanence of endovascular coiling has yet to be established. As far as the safety of clipping or coiling, the study showed no difference in the mortality (death) rate between clipping and coiling. Therefore, no definite conclusions can be made regarding the superiority of one treatment over the other.

A more recent, large study has shown that for ruptured aneurysms suitable for both clipping and endovascular coiling, patients who underwent endovascular coiling had better outcomes at least in the short term (chance of death or disability at one year of 23.5 percent in patients who were coiled versus 30.9 percent in those who underwent clipping). While this study has firmly established endovascular coiling of ruptured aneurysms as an acceptable treatment option, there were limitations inherent to this study.

How do I decide what procedure to have if I have a cerebral aneurysm?
The treatment of choice for an intracranial aneurysm, like all medical decisions, should be agreed upon by both the physician and the patient. In the case of either ruptured or unruptured intracranial aneurysms, the treating physician should discuss the risks and benefits of each available treatment option. The physician will usually make recommendations for one treatment over another, depending on the facts of each individual case. Seeking a second opinion, when possible, is usually advisable.

Although unresolved controversies remain as to the best treatment option for an individual patient, both surgical clipping and endovascular coiling are considered to be viable treatment options in the management of cerebral aneurysms today.

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