Jonathan Latzman
Institution: New York University
Each year there are more than 700,000 strokes in the United States, making it the third leading cause of death and most frequent cause of long-term disability. The mechanisms underlying the often limited functional recovery following a stroke are not clear, as is the potential role of neurogenesis in this recovery. While both stroke and hemorrhage in mice and rats results in new neuron generation in the subventricular zone of the striatum, the pig brain’s reaction to traumatic brain injury and ischemia is relatively more comparable to the human brain than the rodent’s. While striatal hemorrhage is only one-tenth as common as ischemic stroke in humans, it is possible to perform pig studies of the former, while the absence of a circle of Willis and presence of rete mirabilis make stroke studies in pigs exceedingly difficult. The purpose of this study is to characterize the extent of neurogenesis in an experimental model of pig striatal hemorrhage. |