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Current Medical Student Summer Research Fellows

·	Current Medical Student Research Fellows

Matthew Parry Institution: Virginia Commonwealth University A major difficulty facing predictable and efficient convection-enhanced delivery (CED) is the pathological state through which flow is desired: the physical properties of normal tissue are well-understood and allow accurate prediction of the volume (and location) of infusate distribution and concentration. To date, CED into the vasogenic state – partly defined by increased fractional volume of extracellular space -- has been poorly characterized, while a number of animal models of vasogenic edema have been investigated thoroughly. The current proposal seeks to characterize the distribution of dye-labeled albumin delivered via CED into a rodent mannitol-infusion model of vasogenic edema. Histological analysis of specimens will provide a more complete understanding of (1) infusion dynamics (e.g., tissue volume occupied) within the setting of vasogenic edema and (2) the pathology and models themselves.