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Current Medical Student Summer Research Fellows

·	Current Medical Student Research Fellows

Anand Veerauagu Preceptor: Victor Tse, MD, PhD Institution: Stanford University Glioblastoma multiforme (GBM) is the most prevalent and malignant primary brain tumor in adults. The development of novel therapeutics for GBM requires a thorough understanding of tumor angiogenesis and molecular expression. Studies have shown that integrin-avß3 is expressed on glioma tumor cells and plays a critical role in the regulation of tumor growth, invasion, and angiogenesis. MEDI522 is a humanized antibody that specifically recognizes avß3 and is currently in Phase III clinical trials for cancer treatment. The proposed study aims to use U87MG-fluc tumor cells (human glioma cell line), positron emission tomography (PET), bioluminescence imaging (BLI) and a 90Y-labeled MEDI522 antibody to treat glioma growth in an orthotopic brain tumor model. We hypothesize that 90Y-MEDI522 used as an radioimmuntherapeutic against human glioma cells may be efficacious in preventing the growth and initiating the regression of orthotopically placed glioblastoma tumors.