Email to a colleague
View Printer Friendly           Home | Other Research | 2007 Summer Fellowship Opportunity

Current Medical Student Summer Research Fellows

·	Current Medical Student Research Fellows

Doniel Drazin Preceptor: Alan Boulos, MD Institution: Albany Medical Center No neuroprotectants are currently in use for stroke and the only approved treatment, recombinant tissue plasminogen activator (rtPA), is limited to a small percentage of patients. Tamoxifen has been a potent neuroprotectant in rodents and preliminary canine studies. This experiment will test the efficacy of tamoxifen utilizing Albany's Endovascular Canine Stroke Model. It is hypothesized that tamoxifen will be an effective neuroprotectant, significantly decreasing infarct size and improving behavioral outcomes. An autologous clot will be injected through a microcatheter, selectively occluding the middle cerebral artery. Randomly assigned animals will undergo injection of tamoxifen, vehicle and/or rtPA 3 hours post-ischemia. Results will be assessed using angiography, MRI, behavioral and histologic measures. If tamoxifen is an effective neuroprotectant against stroke in large animals, it will likely become a prime candidate for rapid entry into clinical research as it will have met all criteria of the Stroke Treatment Academic Industry Roundtable