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2007 ACS/AANS-NREF Faculty Career Development Award Uzma Samadani, MD, PhD New York University Sponsor: Howard L. Weiner, MD Sonic hedgehog therapy after lysis of intracranial hemorrhage Intracranial hemorrhages result in high morbidity and mortality through several mechanisms including disruption of adjacent white matter tracts. Repair of these tracts may be possible through recruitment of neural progenitor cells induced to proliferate, differentiate and function by signal transduction molecules such as sonic hedgehog. We propose to demonstrate that sonic hedgehog can induce proliferation and differentiation of endogenous stem cells in a model of porcine induced intracranial hemorrhage and lysis. The utilization of small molecule therapy to promote restoration of neurologic function after hemorrhage would have profound implications for the treatment of deficits caused by other mechanisms including stroke and trauma.