Abstract Date: 5/1/2016
Jeremy Steinberger, MD
Nathan Lee, BA
Parth Kothari, BA
Ahmed Awad, MD
Christopher Sarkiss, MD
eric oermann, MD
John Caridi, MD
Raj Shrivastava, MD (New York, NY)
Large scale studies examining the effect of age on outcomes after meningioma surgery have not been performed to date. This study utilizes a large national database to assess the impact of age in adults undergoing surgery for meningioma.
Patients were identified by CPT code in the NSQIP database. Univariate analysis was performed to compare demographics, comorbidities, and postoperative complications in patients of different ages. Multivariate step-wise logistic regression was performed on each complication that demonstrated significant association with age in the univariate comparison.
1,568 patients were identified in the database. On univariate analysis, patients under 50 had overall complication rates of 17.9%, while patients 71-80 had rates of 29.6% and patients above 80 had rates of 31.2% (p<0.0001). Specifically, patients in the 71-80 group and >80 group had higher rates of pulmonary complications, deep venous thromboses/pulmonary embolisms, and urinary tract infections. Patients under 50 had a length of stay greater than 5 days 32.3% of the time, while patients 71-80 and >80 had rates were 49.2% and 64.5%, respectively (p<0.0001) . Age had a significant impact on mortality. Patients under 50 had a 30-day mortality rate of 0.7%, while patients 71-80 had mortality rates of 2.5% and patients >80 had mortality rates of 8.6% (p<0.0001). On multivariate analysis, patients greater than 80 were at higher risk of overall complications (Adjusted OR 2.37, 95% CI 1.30-4.36, p=0.015) and prolonged length of stay (Adjusted OR 3.154, 95% CI 1.78-5.58, p=0.0002). Death within 30 days was greater than 15 times higher in patients >80 than the younger groups (Adjusted OR 15.7, 95% CI 3.03-81.0, p<0.0001).
In evaluating the effect of age in 1,568 patients undergoing meningioma surgery, 80 years old seems to be the statistical cut off for significantly increased morbidity and mortality.
Article ID: AA-34820